GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs11125529 | 1 | rs57060498 | chr2:54479230 | C2orf73 | chr2:54558071-54588714:+ | 0.29 | 4.14 | 4.1E-5 | Telomere length |
| THCA | cis | rs2143950 | 1 | rs57075379 | chr14:35577801 | FAM177A1 | chr14:35514113-35552587:+ | -0.2 | -3.76 | 0.000191 | Atopic dermatitis |
| THCA | cis | rs2143950 | 1 | rs57075379 | chr14:35577801 | KIAA0391 | chr14:35591776-35786673:+ | 0.31 | 5.74 | 1.65E-8 | Atopic dermatitis |
| THCA | cis | rs2143950 | 1 | rs57075379 | chr14:35577801 | PPP2R3C | chr14:35554679-35591679:- | 0.54 | 10.32 | 1.13E-22 | Atopic dermatitis |
| THCA | cis | rs2241437 | 1 | rs57083584 | chr2:86283648 | POLR1A | chr2:86253453-86333278:- | -0.3 | -3.78 | 0.000177 | Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) |
| THCA | cis | rs2129782 | 1 | rs57092235 | chr8:89451205 | MMP16 | chr8:89049462-89339717:- | 0.32 | 5.23 | 2.52E-7 | Electrodermal activity |
| THCA | cis | rs4888671 | 1 | rs57110085 | chr16:77783313 | NUDT7 | chr16:77756411-77776153:+ | 0.36 | 4.92 | 1.21E-6 | Obesity-related traits |
| THCA | cis | rs7742824 | 1 | rs57139546 | chr6:44067745 | TMEM63B | chr6:44095376-44123255:+ | 0.16 | 3.57 | 0.000397 | Major depressive disorder |
| THCA | cis | rs6988636 | 1 | rs57165742 | chr8:124184559 | FAM83A | chr8:124191287-124222317:+ | -0.34 | -4.25 | 2.56E-5 | Urinary uromodulin levels |
| THCA | cis | rs7219021 | 1 | rs57185954 | chr17:46844961 | CALCOCO2 | chr17:46908372-46942228:+ | -0.13 | -3.5 | 0.000501 | Schizophrenia or bipolar disorder |
| THCA | cis | rs7219021 | 1 | rs57185954 | chr17:46844961 | SNF8 | chr17:47007461-47022154:- | -0.25 | -7.39 | 6.82E-13 | Schizophrenia or bipolar disorder |
| THCA | cis | rs7219021 | 1 | rs57185954 | chr17:46844961 | UBE2Z | chr17:46985767-47006422:+ | -0.19 | -4.01 | 6.91E-5 | Schizophrenia or bipolar disorder |
| THCA | cis | rs3771570 | 1 | rs57196672 | chr2:242235193 | ANO7 | chr2:242127924-242164791:+ | 0.36 | 4.26 | 2.5E-5 | Prostate cancer |
| THCA | cis | rs3771570 | 1 | rs57196672 | chr2:242235193 | SEPT2 | chr2:242254723-242293439:+ | -0.28 | -4.22 | 2.9E-5 | Prostate cancer |
| THCA | cis | rs12435908 | 1 | rs57201867 | chr14:66093872 | LOC645431 | chr14:65877313-65879335:- | -0.61 | -7.58 | 1.81E-13 | Ischemic stroke |